An overview on the obsolescence of physical assets for the defence facing the challenges of industry 4.0 and the new operating environments

Libro en Open AccessThis contribution is intended to observe special features presented in physical assets for defence. Particularly, the management of defence assets has to consider not only the reliability, availability, maintainability and other factors frequently used in asset management. On the contrary, such systems should also take into account their adaptation to changing operating environments as well as their capability to changes on the technological context. This study approaches to the current real situation where, due to the diversity of conflicts in our international context, the same type of defence systems must be able to provide services under different boundary conditions in different areas of the globe. At the same time, new concepts from the Industry 4.0 provide quick changes that should be considered along the life cycle of a defence asset. As a finding or consequence, these variations in operating conditions and in technology may accelerate asset degradation by modifying its reliability, its up-to-date status and, in general terms, its end-of-life estimation, depending of course on a diversity of factors. This accelerated deterioration of the asset is often known as “obsolescence” and its implications are often evaluated (when possible), in terms of costs from different natures. The originality of this contribution is the introduction of a discussion on how a proper analysis may help to reduce errors and mistakes in the decision-making process regarding the suitability or not of repairing, replacing, or modernizing the asset or system under study. In other words, the obsolescence analysis, from a reliability and technological point of view, could be used to determine the conservation or not of a specific asset fleet, in order to understand the effects of operational and technology factors variation over the functionality and life cycle cost of physical assets for defence

Cyber physical systems implementation for asset management improvement: A framework for the transition

Libro en Open AccessThe transformation of the industry due to recent technologies introduction is an evolving process whose engines are competitiveness and sustainability, understood in its broadest sense (environmental, economic and social). This process is facing, due to the current state of scientific and technological development, a new challenge yet even more important: the transition from discrete technological solutions that respond to isolated problems, to a global conception where the assets, plant, processes and engineering systems are conceived, designed and operated as an integrated complex unit. This vision is evolving besides a set of concepts that are, in some way, to guide this development: Smart Factories, Cyber-Physical Systems, Factory of the Future or Industry 4.0, are examples. The full integration of the operation and maintenance (O&M) processes in the production systems is a key topic within this new paradigm. Not only that, this evolution necessarily results in the emergence of new processes and needs of O&M, i.e. also, the O&M will undergo a profound transformation. The transition from actual isolated production assets to such Industry 4.0 with CPS is far from easy. This document presents a proposal to develop such transition adapting one iteration of the Model of Maintenance Management (MMM) integrated into ISO 55000 to the complexity of incorporating “System of Systems” CPSs maintenance. It involves several stages: identification, prioritization, risk management, planning, scheduling, execution, control, and improvement supported by system engineering techniques and agile/concurrent project managemen

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio